Alosetron Hydrochloride and Weed
Edited by Hugh Soames
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Alosetron Hydrochloride and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Alosetron Hydrochloride. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Alosetron Hydrochloride and Weed.
Mixing Alosetron Hydrochloride and Weed
Alosetron, sold under the brand name Lotronex among others, is a 5-HT3 antagonist used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in females only.
It was patented in 1987 and approved for medical use in 2002. It is currently marketed by Prometheus Laboratories Inc. (San Diego). Alosetron was withdrawn from the market in 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, but was reintroduced in 2002 with availability and use restricted.
Alosetron is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) who have:
Severe IBS-D includes: diarrhea and 1 or more of the following:
The phase III trial for approval was published in 2000 as an industry-funded randomized, placebo-controlled trial (PCT). Its authors found 1 mg alosetron, taken orally twice daily for 12 weeks, was associated with a 12% (CI 4.7-19.2) improvement in relief from abdominal pain and discomfort associated with diarrhea-predominant patients. The prescription of alosetron is currently approved in the U.S. at 0.5 and 1 mg.
The FDA Medical Officer’s Review, dated November 4, 1999, noted: “Patients considered by investigators to fit the diarrhea-predominant subtype had at baseline… stool consistency values that were neither loose nor watery”. The FDA’s Gastrointestinal Drugs Advisory Committee referred to the drug’s efficacy as “modest”, highlighting that the placebo brought relief on the primary outcome measure to 40–50% of women.
Lotronex’s prescribing information brochure states that alosetron should not be initiated in patients with constipation. Other contraindications are: history of chronic or severe constipation or sequelae from constipation; intestinal obstruction, stricture, toxic megacolon, gastrointestinal perforation, and/or adhesions, ischemic colitis, impaired intestinal circulation, thrombophlebitis, or hypercoagulable state; Crohn’s disease or ulcerative colitis; diverticulitis; severe hepatic impairment. Concomitant use of fluvoxamine is also contraindicated.
Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects. The cumulative incidence of ischaemic colitis was 2 in 1000, while serious complications arising from constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 in 1000. A 1999 review performed by FDA medical officer John Senior, indicated that 27% of patients experienced constipation. The phase III trial reported constipation occurred in 30% and 3% of patients in the alosetron and placebo groups, respectively. It was cited as the most important reason for patients dropping out of the study.
Alosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron’s 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products.
Alosetron was originally approved by the U.S. Food and Drug Administration (FDA) on February 9, 2000, after a seven-month review. At the time of the initial approval U.S. Food and Drug Administration (FDA) reviewers found that alosetron improved symptoms in 10% to 20% of patients.
Shipment to pharmacies started in March, 2000. On July 17, a health professional filed a report with the FDA on the death of a 50-year-old woman who suffered mesenteric ischemia. The report identified alosetron as the “primary suspect” in the death.
Alosetron was withdrawn from the market voluntarily by GlaxoWellcome on November 28, 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, including 5 deaths and additional bowel surgeries. The FDA said it had reports of 49 cases of ischemic colitis and 21 cases of “severe constipation” and that ten of the 70 patients underwent surgeries and 34 others were examined at hospitals and released without surgery. Through November 17, 2000, pharmacists had filled 474,115 prescriptions for alosetron. Severe adverse events continued to be reported, with a final total of 84 instances of ischaemic colitis, 113 of severe constipation, 143 admissions to hospital, and 7 deaths.
Patient advocacy groups, most notably the Lotronex Action Group and the International Foundation for Functional Gastrointestinal Disorders (IFFGD) lobbied for the drug’s return. Public Citizen Health Research Group, another patient advocacy group, opposed the reintroduction.
On June 7, 2002, the FDA announced the approval of a supplemental New Drug Application (sNDA) that allows restricted marketing of Lotronex (alosetron hydrochloride), to treat only women with severe diarrhea-predominant irritable bowel syndrome (IBS). The strict prescribing guidelines initially introduced in 2002 were relaxed slightly in 2016, enabling electronic prescriptions among other benefits.
It is not known whether alosetron has been filed for registration in the EU.
GSK sold Lotronex to the Californian corporation Prometheus in late 2007.
Since 2015, generic versions of alosetron have been available in the US, sold by a number of different companies including Actavis Pharma Company, Prometheus Laboratories and Sebela Pharmaceuticals Inc
In 2001, the editor of the renowned medical journal The Lancet, Richard Horton, criticized the FDA’s handling of alosetron in an unusually sharp language. Horton argued that the treatment of a non-fatal condition did not justify the use of a drug with potentially lethal side effects, and that the FDA should have revoked the approval for alosetron sooner when postmarketing surveillance revealed that many patients had suffered constipation necessitating surgical intervention and ischaemic colitis. He asserted that FDA officials were improperly motivated to maintain and reinstate the approval for alosetron because of the extent to which the FDA’s Center for Drug Evaluation and Research is funded by user fees paid by pharmaceutical manufacturers, and that the reinstatement of alosetron was negotiated in confidential meetings with representatives of GlaxoSmithKline.
An article published in the British Medical Journal (BMJ) noted: “By allowing the marketing of alosetron, a drug that poses a serious and significant public health concern according to its own terms, the FDA failed in its mission.” Others have argued that the approval process of Lotronex was an example of regulatory capture.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Alosetron Hydrochloride and Weed and an increase in anxiety.
Anyone mixing Alosetron Hydrochloride and weed is likely to experience side effects. This happens with all medications whether weed or Alosetron Hydrochloride is mixed with them. Side effects can be harmful when mixing Alosetron Hydrochloride and weed. Doctors are likely to refuse a patient a Alosetron Hydrochloride prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Alosetron Hydrochloride and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Alosetron Hydrochloride are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Alosetron Hydrochloride. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Alosetron Hydrochloride and Weed, dol not interact is wrong. There will always be an interaction between Alosetron Hydrochloride and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Alosetron Hydrochloride and Weed is Scromiting. This condition, reportedly caused by mixing Alosetron Hydrochloride and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Alosetron Hydrochloride and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Alosetron Hydrochloride and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Alosetron Hydrochloride?
The way in which the body absorbs and process Alosetron Hydrochloride may be affected by weed. Therefore, the potency of the Alosetron Hydrochloride may be less effective. Marijuana inhibits the metabolization of Alosetron Hydrochloride. Not having the right potency of Alosetron Hydrochloride means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Alosetron Hydrochloride medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Alosetron Hydrochloride medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Alosetron Hydrochloride and Weed
Many individuals may not realize that there are side effects and consequences to mixing Alosetron Hydrochloride and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Alosetron Hydrochloride and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Alosetron Hydrochloride and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Alosetron Hydrochloride and Weed is not recommended.
Taking Alosetron Hydrochloride and Weed together
People who take Alosetron Hydrochloride and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Alosetron Hydrochloride and weed depend on whether you consume more weed in relation to Alosetron Hydrochloride or more Alosetron Hydrochloride in relation to weed.
The use of significantly more weed and Alosetron Hydrochloride will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alosetron Hydrochloride may experience effects such as:
- reduced motor reflexes from Alosetron Hydrochloride and Weed
- dizziness from Weed and Alosetron Hydrochloride
- nausea and vomiting due to Alosetron Hydrochloride and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alosetron Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Alosetron Hydrochloride
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Alosetron Hydrochloride this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Alosetron Hydrochloride affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Alosetron Hydrochloride and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Alosetron Hydrochloride can be just as harmful and there is no way of knowing exactly how Alosetron Hydrochloride and weed is going to affect an individual before they take it.
Taking Alosetron Hydrochloride and weed together
People who take Alosetron Hydrochloride and weed together will experience the effects of both substances. The use of significantly more Alosetron Hydrochloride with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alosetron Hydrochloride may experience effects such as:
- reduced motor reflexes from Alosetron Hydrochloride and weed
- dizziness from weed and Alosetron Hydrochloride
- nausea and vomiting of the Alosetron Hydrochloride
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alosetron Hydrochloride leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Alosetron Hydrochloride
Taking Alosetron Hydrochloride in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Alosetron Hydrochloride and weed may have difficulty forming new memories. With weed vs Alosetron Hydrochloride in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Alosetron Hydrochloride when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Alosetron Hydrochloride and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Alosetron Hydrochloride Vs Weed
Studies investigating the effects of drugs such as Alosetron Hydrochloride and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Alosetron Hydrochloride and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Alosetron Hydrochloride together.
When a small to medium amount of weed is combined with Alosetron Hydrochloride, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Alosetron Hydrochloride.
How long after taking Alosetron Hydrochloride can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Alosetron Hydrochloride has totally cleared your system before taking weed, even in small quantities.
Overdose on Alosetron Hydrochloride and weed
In the case of Overdose on Alosetron Hydrochloride or if you are worried after mixing Alosetron Hydrochloride and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Alosetron Hydrochloride or mixed weed with Alosetron Hydrochloride then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Alosetron Hydrochloride and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Alosetron Hydrochloride and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Alosetron Hydrochloride and weed. These individuals may not realize that there are side effects and consequences to consuming both Alosetron Hydrochloride, marijuana and a range of antidepressants.
Studies on weed, Alosetron Hydrochloride and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Alosetron Hydrochloride
A lot of people suffer from depression caused by weed and Alosetron Hydrochloride. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Alosetron Hydrochloride and weed
Quitting weed to take Alosetron Hydrochloride
Medical professionals say an individual prescribed or taking Alosetron Hydrochloride should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Alosetron Hydrochloride.
A person beginning to use Alosetron Hydrochloride should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Alosetron Hydrochloride can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Alosetron Hydrochloride may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Alosetron Hydrochloride and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Alosetron Hydrochloride or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Alosetron Hydrochloride from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Alosetron Hydrochloride.
If you take Alosetron Hydrochloride, and also drink Alcohol or MDMA, you can research the effects of Alosetron Hydrochloride and Alcohol , Alosetron Hydrochloride and Cocaine as well as Alosetron Hydrochloride and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Alosetron Hydrochloride and Weed
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