Alendronate Sodium and Weed
Edited by Hugh Soames
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Alendronate Sodium and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Alendronate Sodium. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Alendronate Sodium and Weed.
Mixing Alendronate Sodium and Weed
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget’s disease of bone. It is taken by mouth. Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.
Common side effects (1 to 10% of patients) include constipation, abdominal pain, nausea, and acid reflux. Use is not recommended during pregnancy or in those with poor kidney function. Alendronic acid works by decreasing the activity of cells that break down bone.
Alendronic acid was first described in 1978 and approved for medical use in the United States in 1995. It is available as a generic medication. In 2020, it was the 94th most commonly prescribed medication in the United States, with more than 7 million prescriptions.
Alendronate should not be used in:
Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic pyrophosphate, the endogenous regulator of bone turnover. But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. Its inhibition of bone-resorption is dose-dependent and approximately 1,000 times stronger than the equimolar effect of the first bisphosphonate drug, etidronate. Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in a pharmacologically inactive form. For optimal action, enough calcium and vitamin D are needed in the body in order to promote normal bone development. Hypocalcemia should, therefore, be corrected before starting therapy.
Etidronate has the same disadvantage as pyrophosphate in inhibiting mineralization, but all of the potent N-containing bisphosphonates, including alendronate, risedronate, ibandronate, and zoledronate, do not.
As with all potent bisphosphonates, the fraction of the drug that reaches the circulatory system intact (systemic bioavailability) after oral dosing is low, averaging only 0.6–0.7% in women and in men under fasting conditions. Intake together with meals and beverages other than water further reduces the bioavailability. The absorbed drug rapidly partitions, with approximately 50% binding to the exposed bone surface; the remainder is excreted unchanged by the kidneys. Unlike with most drugs, the strong negative charge on the two phosphonate moieties limits oral bioavailability, and, in turn, the exposure to tissues other than bone is very low. After absorption in the bone, alendronate has an estimated terminal elimination half-life of 10 years.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Alendronate Sodium and Weed and an increase in anxiety.
Anyone mixing Alendronate Sodium and weed is likely to experience side effects. This happens with all medications whether weed or Alendronate Sodium is mixed with them. Side effects can be harmful when mixing Alendronate Sodium and weed. Doctors are likely to refuse a patient a Alendronate Sodium prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Alendronate Sodium and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Alendronate Sodium are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Alendronate Sodium. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Alendronate Sodium and Weed, dol not interact is wrong. There will always be an interaction between Alendronate Sodium and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Alendronate Sodium and Weed is Scromiting. This condition, reportedly caused by mixing Alendronate Sodium and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Alendronate Sodium and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Alendronate Sodium and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Alendronate Sodium?
The way in which the body absorbs and process Alendronate Sodium may be affected by weed. Therefore, the potency of the Alendronate Sodium may be less effective. Marijuana inhibits the metabolization of Alendronate Sodium. Not having the right potency of Alendronate Sodium means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Alendronate Sodium medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Alendronate Sodium medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Alendronate Sodium and Weed
Many individuals may not realize that there are side effects and consequences to mixing Alendronate Sodium and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Alendronate Sodium and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Alendronate Sodium and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Alendronate Sodium and Weed is not recommended.
Taking Alendronate Sodium and Weed together
People who take Alendronate Sodium and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Alendronate Sodium and weed depend on whether you consume more weed in relation to Alendronate Sodium or more Alendronate Sodium in relation to weed.
The use of significantly more weed and Alendronate Sodium will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alendronate Sodium may experience effects such as:
- reduced motor reflexes from Alendronate Sodium and Weed
- dizziness from Weed and Alendronate Sodium
- nausea and vomiting due to Alendronate Sodium and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alendronate Sodium leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Alendronate Sodium
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Alendronate Sodium this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Alendronate Sodium affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Alendronate Sodium and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Alendronate Sodium can be just as harmful and there is no way of knowing exactly how Alendronate Sodium and weed is going to affect an individual before they take it.
Taking Alendronate Sodium and weed together
People who take Alendronate Sodium and weed together will experience the effects of both substances. The use of significantly more Alendronate Sodium with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Alendronate Sodium may experience effects such as:
- reduced motor reflexes from Alendronate Sodium and weed
- dizziness from weed and Alendronate Sodium
- nausea and vomiting of the Alendronate Sodium
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Alendronate Sodium leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Alendronate Sodium
Taking Alendronate Sodium in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Alendronate Sodium and weed may have difficulty forming new memories. With weed vs Alendronate Sodium in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Alendronate Sodium when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Alendronate Sodium and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Alendronate Sodium Vs Weed
Studies investigating the effects of drugs such as Alendronate Sodium and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Alendronate Sodium and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Alendronate Sodium together.
When a small to medium amount of weed is combined with Alendronate Sodium, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Alendronate Sodium.
How long after taking Alendronate Sodium can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Alendronate Sodium has totally cleared your system before taking weed, even in small quantities.
Overdose on Alendronate Sodium and weed
In the case of Overdose on Alendronate Sodium or if you are worried after mixing Alendronate Sodium and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Alendronate Sodium or mixed weed with Alendronate Sodium then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Alendronate Sodium and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Alendronate Sodium and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Alendronate Sodium and weed. These individuals may not realize that there are side effects and consequences to consuming both Alendronate Sodium, marijuana and a range of antidepressants.
Studies on weed, Alendronate Sodium and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Alendronate Sodium
A lot of people suffer from depression caused by weed and Alendronate Sodium. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Alendronate Sodium and weed
Quitting weed to take Alendronate Sodium
Medical professionals say an individual prescribed or taking Alendronate Sodium should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Alendronate Sodium.
A person beginning to use Alendronate Sodium should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Alendronate Sodium can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Alendronate Sodium may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Alendronate Sodium and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Alendronate Sodium or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Alendronate Sodium from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Alendronate Sodium.
If you take Alendronate Sodium, and also drink Alcohol or MDMA, you can research the effects of Alendronate Sodium and Alcohol , Alendronate Sodium and Cocaine as well as Alendronate Sodium and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Alendronate Sodium and Weed
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