Agrylin and Weed
Edited by Hugh Soames
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Agrylin and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Agrylin. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Agrylin and Weed.
Mixing Agrylin and Weed
Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also known as essential thrombocythemia), or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia.
Anagrelide controlled release (GALE-401) is in phase III clinical trials by Galena Biopharma for the treatment of essential thrombocytosis.
Anagrelide is used to treat essential thrombocytosis, especially when the current treatment of the patient is insufficient. Essential thrombocytosis patients who are suitable for anagrelide often meet one or more of the following factors:
According to a 2005 Medical Research Council randomized trial, the combination of hydroxyurea with aspirin is superior to the combination of anagrelide and aspirin for the initial management of essential thrombocytosis. The hydroxyurea arm had a lower likelihood of myelofibrosis, arterial thrombosis, and bleeding, but it had a slightly higher rate of venous thrombosis. Anagrelide can be useful in times when hydroxyurea proves ineffective.
Common side effects are headache, diarrhea, unusual weakness/fatigue, hair loss, nausea.
The same MRC trial mentioned above also analyzed the effects of anagrelide on bone marrow fibrosis, a common feature in patients with myelofibrosis. The use of anagrelide was associated with a rapid increase in the degree of reticulin deposition (the mechanism by which fibrosis occurs), when compared to those in whom hydroxyurea was used. Patients with myeloproliferative conditions are known to have a very slow and somewhat variable course of marrow fibrosis increase. This trend may be accelerated by anagrelide. This increase in fibrosis appeared to be linked to a drop in hemoglobin as it progressed. Stopping anagrelide (and switching patients to hydroxyurea) appeared to reverse the degree of marrow fibrosis. Thus, patients on anagrelide may need to be monitored on a periodic basis for marrow reticulin scores, especially if anemia develops, or becomes more pronounced if present initially.
Less common side effects include: congestive heart failure, myocardial infarction, cardiomyopathy, cardiomegaly, complete heart block, atrial fibrillation, cerebrovascular accident, pericarditis, pulmonary infiltrates, pulmonary fibrosis, pulmonary hypertension, pancreatitis, gastric/duodenal ulceration, renal impairment/failure and seizure.
Due to these issues, anagrelide should not generally be considered for first line therapy for essential thrombocytosis.
Anagrelide works by inhibiting the maturation of platelets from megakaryocytes. The exact mechanism of action is unclear, although it is known to be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM) inhibitor of phosphodiesterase-II. It inhibits PDE-3 and phospholipase A2.
Condensation of benzyl chloride 1 with ethyl ester of glycine gives alkylated product 2. Reduction of the nitro group leads to the aniline and reaction of this with cyanogen bromide possibly gives cyanamide 3 as the initial intermediate. Addition of the aliphatic would then lead to formation of the quinazoline ring (4). Amide formation between the newly formed imide and the ester would then serve to form the imidazolone ring, whatever the details of the sequence, there is obtained anagrelide (5).
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Agrylin and Weed and an increase in anxiety.
Anyone mixing Agrylin and weed is likely to experience side effects. This happens with all medications whether weed or Agrylin is mixed with them. Side effects can be harmful when mixing Agrylin and weed. Doctors are likely to refuse a patient a Agrylin prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Agrylin and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Agrylin are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Agrylin. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Agrylin and Weed, dol not interact is wrong. There will always be an interaction between Agrylin and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Agrylin and Weed is Scromiting. This condition, reportedly caused by mixing Agrylin and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Agrylin and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Agrylin and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Agrylin?
The way in which the body absorbs and process Agrylin may be affected by weed. Therefore, the potency of the Agrylin may be less effective. Marijuana inhibits the metabolization of Agrylin. Not having the right potency of Agrylin means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Agrylin medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Agrylin medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Agrylin and Weed
Many individuals may not realize that there are side effects and consequences to mixing Agrylin and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Agrylin and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Agrylin and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Agrylin and Weed is not recommended.
Taking Agrylin and Weed together
People who take Agrylin and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Agrylin and weed depend on whether you consume more weed in relation to Agrylin or more Agrylin in relation to weed.
The use of significantly more weed and Agrylin will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Agrylin may experience effects such as:
- reduced motor reflexes from Agrylin and Weed
- dizziness from Weed and Agrylin
- nausea and vomiting due to Agrylin and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Agrylin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Agrylin
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Agrylin this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Agrylin affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Agrylin and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Agrylin can be just as harmful and there is no way of knowing exactly how Agrylin and weed is going to affect an individual before they take it.
Taking Agrylin and weed together
People who take Agrylin and weed together will experience the effects of both substances. The use of significantly more Agrylin with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Agrylin may experience effects such as:
- reduced motor reflexes from Agrylin and weed
- dizziness from weed and Agrylin
- nausea and vomiting of the Agrylin
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Agrylin leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Agrylin
Taking Agrylin in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Agrylin and weed may have difficulty forming new memories. With weed vs Agrylin in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Agrylin when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Agrylin and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Agrylin Vs Weed
Studies investigating the effects of drugs such as Agrylin and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Agrylin and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Agrylin together.
When a small to medium amount of weed is combined with Agrylin, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Agrylin.
How long after taking Agrylin can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Agrylin has totally cleared your system before taking weed, even in small quantities.
Overdose on Agrylin and weed
In the case of Overdose on Agrylin or if you are worried after mixing Agrylin and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Agrylin or mixed weed with Agrylin then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Agrylin and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Agrylin and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Agrylin and weed. These individuals may not realize that there are side effects and consequences to consuming both Agrylin, marijuana and a range of antidepressants.
Studies on weed, Agrylin and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Agrylin
A lot of people suffer from depression caused by weed and Agrylin. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Agrylin and weed
Quitting weed to take Agrylin
Medical professionals say an individual prescribed or taking Agrylin should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Agrylin.
A person beginning to use Agrylin should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Agrylin can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Agrylin may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Agrylin and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Agrylin or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Agrylin from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Agrylin.
If you take Agrylin, and also drink Alcohol or MDMA, you can research the effects of Agrylin and Alcohol , Agrylin and Cocaine as well as Agrylin and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Agrylin and Weed
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