Adipex-P and Weed
Edited by Hugh Soames
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Adipex-P and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Adipex-P. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Adipex-P and Weed.
Mixing Adipex-P and Weed
Phentermine (phenyl-tertiary-butylamine), with several brand names including Ionamin and Sentis, is a medication used together with diet and exercise to treat obesity. It is taken by mouth for up to a few weeks at a time, after which the benefits subside. It is also available as the combination phentermine/topiramate.
Common side effects include a fast heart beat, high blood pressure, trouble sleeping, dizziness, and restlessness. Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter were caused by the fenfluramine component of the fen-phen drug combination. Use is not recommended during pregnancy or breastfeeding, or with SSRIs or MAO inhibitors. It works mainly as an appetite suppressant, likely as a result of being a CNS stimulant. Chemically, phentermine is a substituted amphetamine.
Phentermine was approved for medical use in the United States in 1959. It is available as a generic medication. In 2020, it was the 181st most commonly prescribed medication in the United States, with more than 3 million prescriptions. Phentermine was withdrawn from the market in the United Kingdom in 2000, while the combination medication fen-phen, of which it was a part, was withdrawn from the market in 1997 due to side effects of fenfluramine which caused increased levels of circulating serotonin which stimulated serotonin receptors on heart valves and thus causing valve insufficiency and leading to primary pulmonary hypertension (PPH). According to the NIH (National Institutes of Health) there is no evidence that phentermine causes PPH.[citation needed]
Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction.
Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks. However, significant loss continues through the sixth month and has been shown to continue at a slower rate through the ninth month.
Phentermine is contraindicated for users who:
Tolerance usually occurs; however, risks of dependence and addiction are considered negligible. People taking phentermine may be impaired when driving or operating machinery. Consumption of alcohol with phentermine may produce adverse effects.
There is currently no evidence regarding whether or not phentermine is safe for pregnant women.
Other adverse effects include:
Phentermine may decrease the effect of drugs like clonidine, methyldopa, and guanethidine. Drugs to treat hypothyroidism may increase the effect of phentermine.
Phentermine has some similarity in its pharmacodynamics with its parent compound, amphetamine, as they both are TAAR1 agonists, where the activation of TAAR1 in monoamine neurons facilitates the efflux, or release into the synapse, of these neurochemicals. At clinically relevant doses, phentermine primarily acts as a releasing agent of norepinephrine in neurons, although, to a lesser extent, it releases dopamine and serotonin into synapses as well. Phentermine may also trigger the release of monoamines from VMAT2, which is a common pharmacodynamic effect among substituted amphetamines. The primary mechanism of phentermine’s action in treating obesity is the reduction of hunger perception, which is a cognitive process mediated primarily through several nuclei within the hypothalamus (in particular, the lateral hypothalamic nucleus, arcuate nucleus, and ventromedial nucleus). Outside the brain, phentermine releases norepinephrine and epinephrine – also known as noradrenaline and adrenaline respectively – causing fat cells to break down stored fat as well.
In 1959, phentermine first received approval from the United States FDA as an appetite-suppressing drug. Eventually a hydrochloride salt and a resin form became available.
Phentermine was marketed with fenfluramine or dexfenfluramine as a combination appetite suppressant and fat burning agent under the popular name fen-phen. In 1997, after 24 cases of heart valve disease in fen-phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Studies later showed nearly 30% of people taking fenfluramine or dexfenfluramine for up to 24 months had abnormal valve findings.
Phentermine is still available by itself in most countries, including the US. However, because it is similar to amphetamine, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act. In contrast, amphetamine preparations are classified as Schedule II controlled substances.
A company called Vivus developed a combination drug, phentermine/topiramate that it originally called Qnexa and then called Qsymia, which was invented and used off-label by Thomas Najarian, who opened a weight-clinic in Los Osos, California in 2001; Najarian had previously worked at Interneuron Pharmaceuticals, which had developed one of the fen-phen drugs previously withdrawn from the market. The FDA rejected the combination drug in 2010 due to concerns over its safety. In 2012 the FDA approved it after Vivus re-applied with further safety data. At the time, one obesity specialist estimated that around 70% of his colleagues were already prescribing the combination off-label.
Phentermine is a substituted amphetamine which has a methyl group on amphetamine’s alpha carbon. It is a positional isomer of methamphetamine and other methylamphetamines. The molecular formula of phentermine is C10H15N.
Phentermine is contracted from phenyl-tertiary-butylamine.
It is marketed under many brand names and formulations worldwide, including Acxion, Adipex, Adipex-P, Duromine, Elvenir, Fastin, Ionamin, Lomaira (phentermine hydrochloride), Panbesy, Qsymia (phentermine and topiramate), Razin, Redusa, Sentis, Suprenza, and Terfamex.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Adipex-P and Weed and an increase in anxiety.
Anyone mixing Adipex-P and weed is likely to experience side effects. This happens with all medications whether weed or Adipex-P is mixed with them. Side effects can be harmful when mixing Adipex-P and weed. Doctors are likely to refuse a patient a Adipex-P prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Adipex-P and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Adipex-P are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Adipex-P. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Adipex-P and Weed, dol not interact is wrong. There will always be an interaction between Adipex-P and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Adipex-P and Weed is Scromiting. This condition, reportedly caused by mixing Adipex-P and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Adipex-P and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Adipex-P and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Adipex-P?
The way in which the body absorbs and process Adipex-P may be affected by weed. Therefore, the potency of the Adipex-P may be less effective. Marijuana inhibits the metabolization of Adipex-P. Not having the right potency of Adipex-P means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Adipex-P medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Adipex-P medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Adipex-P and Weed
Many individuals may not realize that there are side effects and consequences to mixing Adipex-P and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Adipex-P and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Adipex-P and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Adipex-P and Weed is not recommended.
Taking Adipex-P and Weed together
People who take Adipex-P and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Adipex-P and weed depend on whether you consume more weed in relation to Adipex-P or more Adipex-P in relation to weed.
The use of significantly more weed and Adipex-P will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Adipex-P may experience effects such as:
- reduced motor reflexes from Adipex-P and Weed
- dizziness from Weed and Adipex-P
- nausea and vomiting due to Adipex-P and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Adipex-P leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Adipex-P
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Adipex-P this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Adipex-P affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Adipex-P and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Adipex-P can be just as harmful and there is no way of knowing exactly how Adipex-P and weed is going to affect an individual before they take it.
Taking Adipex-P and weed together
People who take Adipex-P and weed together will experience the effects of both substances. The use of significantly more Adipex-P with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Adipex-P may experience effects such as:
- reduced motor reflexes from Adipex-P and weed
- dizziness from weed and Adipex-P
- nausea and vomiting of the Adipex-P
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Adipex-P leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Adipex-P
Taking Adipex-P in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Adipex-P and weed may have difficulty forming new memories. With weed vs Adipex-P in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Adipex-P when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Adipex-P and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Adipex-P Vs Weed
Studies investigating the effects of drugs such as Adipex-P and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Adipex-P and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Adipex-P together.
When a small to medium amount of weed is combined with Adipex-P, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Adipex-P.
How long after taking Adipex-P can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Adipex-P has totally cleared your system before taking weed, even in small quantities.
Overdose on Adipex-P and weed
In the case of Overdose on Adipex-P or if you are worried after mixing Adipex-P and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Adipex-P or mixed weed with Adipex-P then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Adipex-P and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Adipex-P and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Adipex-P and weed. These individuals may not realize that there are side effects and consequences to consuming both Adipex-P, marijuana and a range of antidepressants.
Studies on weed, Adipex-P and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Adipex-P
A lot of people suffer from depression caused by weed and Adipex-P. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Adipex-P and weed
Quitting weed to take Adipex-P
Medical professionals say an individual prescribed or taking Adipex-P should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Adipex-P.
A person beginning to use Adipex-P should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Adipex-P can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Adipex-P may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Adipex-P and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Adipex-P or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Adipex-P from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Adipex-P.
If you take Adipex-P, and also drink Alcohol or MDMA, you can research the effects of Adipex-P and Alcohol , Adipex-P and Cocaine as well as Adipex-P and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Adipex-P and Weed
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