Adapalene and Weed
Edited by Hugh Soames
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Adapalene and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Adapalene. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Adapalene and Weed.
Mixing Adapalene and Weed
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Studies have found adapalene is as effective as other retinoids, while causing less irritation. It also has several advantages over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is also chemically more stable compared to the other two retinoids, allowing it to be used in combination with benzoyl peroxide. Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. The Swiss company Galderma sells adapalene under the brand-name product Differin.
Per the recommendations of the Global Alliance on Improving Outcomes of Acne, retinoids such as adapalene are considered first-line therapy in acne treatment and are to be used either independently or in conjunction with benzoyl peroxide and/or an antimicrobial agent, like clindamycin, for maximum efficacy. Furthermore, adapalene, like other retinoids, increases the efficacy and penetration of other topical acne medications that are used in conjunction with topical retinoids as well as hastens the improvement of the post-inflammatory hyperpigmentation caused by acne. In the long term, it can be used as maintenance therapy.
Adapalene has the unique ability to inhibit keratinocyte differentiation and decrease keratin deposition. This property makes adapalene an effective treatment for keratosis pilaris and callus. It may be used by men undergoing foreskin restoration to reduce excess keratin that forms a layer on the exterior of the human penis after circumcision. Other non-FDA approved indications that have been reported in the literature include treatment of warts, molluscum contagiosum, Darier disease, photoaging, pigmentary disorders, actinic keratoses and alopecia areata.
Adapalene is known to cause mild adverse effects such as photosensitivity, irritation, redness, dryness, itching, and burning. It is common (between 1% and 10% of users) to experience a brief sensation of warmth or stinging, as well as dry skin, peeling and redness during the first 2–4 weeks of using the medication. These effects are considered mild and generally decrease over time. Any serious allergic reaction is rare. Furthermore, of the three topical retinoids, adapalene is often regarded as the most tolerable.
Use of topical adapalene in pregnancy has not been well studied, but has a theoretical risk of retinoid embryopathy. Thus far, there is no evidence that the cream causes problems in the baby if used during pregnancy. Use is at the consumer’s own risk.
Topical adapalene has poor systemic absorption and results in low blood levels (less than 0.025 mcg/L) even after long term use, suggesting that there is low risk of harm for a nursing infant. However, it is recommended that the topical medication should not be applied to the nipple or any other area that may come into direct contact with the infant’s skin.
Adapalene has been shown to enhance the efficacy of topical clindamycin, although adverse effects are also increased. Application of adapalene gel to the skin 3–5 minutes before application of clindamycin enhances penetration of clindamycin into the skin, which may enhance the overall efficacy of the treatment as compared to clindamycin alone.
Unlike the retinoid tretinoin (Retin-A), adapalene has also been shown to retain its efficacy when applied at the same time as benzoyl peroxide due to its more stable chemical structure. Furthermore, photodegradation of the molecule is less of a concern in comparison to tretinoin and tazarotene.
Absorption of adapalene through the skin is low. A study with six acne patients treated once daily for five days with two grams of adapalene cream applied to 1,000 cm (160 sq in) of skin found no quantifiable amounts, or less than 0.35 ng/mL of the drug, in the patients’ blood plasma. Controlled trials of chronic users of adapalene have found drug levels in the patients’ plasma to be 0.25 ng/mL.
Adapalene is highly lipophilic. When applied topically, it readily penetrates hair follicles and absorption occurs five minutes after topical application. After penetration into the follicle, adapalene binds to nuclear retinoic acid receptors (namely retinoic acid receptor beta and gamma). These complexes then bind to the retinoid X receptor which induces gene transcription by binding to specific DNA sites, thus modulating downstream keratinocyte proliferation and differentiation. This results in normalization of keratinocyte differentiation, allowing for decreased microcomedone formation, decreased clogging of pores, and increased exfoliation by increasing cell turnover. Adapalene is also regarded as an anti-inflammatory agent, as it suppresses the inflammatory response stimulated by the presence of Cutibacterium acnes, and inhibits both lipoxygenase activity and the oxidative metabolism of arachidonic acid into prostaglandins.
Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma when applied to epithelial cells such as those found in the skin. Its agonism of the gamma subtype is largely responsible for adapalene’s observed effects. In fact, when adapalene is applied in conjunction with a retinoic acid receptor gamma antagonist, adapalene loses clinical efficacy.
Retinization is a common temporary phenomenon reported by patients when initiating use of retinoids. Within the initial period of treatment, skin can become red, irritated, dry and may burn or itch from retinoid application; however, this tends to resolve within four weeks with once a day use.
Adapalene was a research product of the Swiss company Galderma’s French subsidiary Galderma Laboratories. Adapalene was approved in 1996 by the U.S. Food and Drug Administration (FDA) for use in the treatment of acne.
A study has concluded that adapalene can be used to treat plantar warts and may help clear lesions faster than cryotherapy. Computational study claims that the adapalene can be used as a potential entry inhibitor for Omicron variant of SARS-CoV2.
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Adapalene and Weed and an increase in anxiety.
Anyone mixing Adapalene and weed is likely to experience side effects. This happens with all medications whether weed or Adapalene is mixed with them. Side effects can be harmful when mixing Adapalene and weed. Doctors are likely to refuse a patient a Adapalene prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Adapalene and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Adapalene are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Adapalene. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Adapalene and Weed, dol not interact is wrong. There will always be an interaction between Adapalene and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Adapalene and Weed is Scromiting. This condition, reportedly caused by mixing Adapalene and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Adapalene and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Adapalene and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Adapalene?
The way in which the body absorbs and process Adapalene may be affected by weed. Therefore, the potency of the Adapalene may be less effective. Marijuana inhibits the metabolization of Adapalene. Not having the right potency of Adapalene means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Adapalene medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Adapalene medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Adapalene and Weed
Many individuals may not realize that there are side effects and consequences to mixing Adapalene and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Adapalene and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Adapalene and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Adapalene and Weed is not recommended.
Taking Adapalene and Weed together
People who take Adapalene and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Adapalene and weed depend on whether you consume more weed in relation to Adapalene or more Adapalene in relation to weed.
The use of significantly more weed and Adapalene will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Adapalene may experience effects such as:
- reduced motor reflexes from Adapalene and Weed
- dizziness from Weed and Adapalene
- nausea and vomiting due to Adapalene and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Adapalene leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Adapalene
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Adapalene this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Adapalene affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Adapalene and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Adapalene can be just as harmful and there is no way of knowing exactly how Adapalene and weed is going to affect an individual before they take it.
Taking Adapalene and weed together
People who take Adapalene and weed together will experience the effects of both substances. The use of significantly more Adapalene with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Adapalene may experience effects such as:
- reduced motor reflexes from Adapalene and weed
- dizziness from weed and Adapalene
- nausea and vomiting of the Adapalene
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Adapalene leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Adapalene
Taking Adapalene in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Adapalene and weed may have difficulty forming new memories. With weed vs Adapalene in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Adapalene when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Adapalene and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Adapalene Vs Weed
Studies investigating the effects of drugs such as Adapalene and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Adapalene and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Adapalene together.
When a small to medium amount of weed is combined with Adapalene, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Adapalene.
How long after taking Adapalene can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Adapalene has totally cleared your system before taking weed, even in small quantities.
Overdose on Adapalene and weed
In the case of Overdose on Adapalene or if you are worried after mixing Adapalene and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Adapalene or mixed weed with Adapalene then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Adapalene and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Adapalene and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Adapalene and weed. These individuals may not realize that there are side effects and consequences to consuming both Adapalene, marijuana and a range of antidepressants.
Studies on weed, Adapalene and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Adapalene
A lot of people suffer from depression caused by weed and Adapalene. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Adapalene and weed
Quitting weed to take Adapalene
Medical professionals say an individual prescribed or taking Adapalene should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Adapalene.
A person beginning to use Adapalene should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Adapalene can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Adapalene may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Adapalene and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Adapalene or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Adapalene from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Adapalene.
If you take Adapalene, and also drink Alcohol or MDMA, you can research the effects of Adapalene and Alcohol , Adapalene and Cocaine as well as Adapalene and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Adapalene and Weed
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