Abacavir Sulfate and Weed
Edited by Hugh Soames
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Abacavir Sulfate and Weed
Most people who consume marijuana do so for its mood-altering and relaxing abilities. Weed gives people a high and allows them to relax. However, heavy consumption of weed can cause unwanted results. It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Abacavir Sulfate. It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Abacavir Sulfate and Weed.
Mixing Abacavir Sulfate and Weed
Abacavir, sold under the brand name Ziagen among others, is a medication used to treat HIV/AIDS. Similar to other nucleoside analog reverse-transcriptase inhibitors (NRTIs), abacavir is used together with other HIV medications, and is not recommended by itself. It is taken by mouth as a tablet or solution and may be used in children over the age of three months.
Abacavir is generally well tolerated. Common side effects include vomiting, insomnia (trouble sleeping), fever, and feeling tired. Other common side effects include loss of appetite, headache, nausea (feeling sick), diarrhea, rash, and lethargy (lack of energy). More severe side effects include hypersensitivity, liver damage, and lactic acidosis. Genetic testing can indicate whether a person is at higher risk of developing hypersensitivity. Symptoms of hypersensitivity include rash, vomiting, and shortness of breath. Abacavir is in the NRTI class of medications, which work by blocking reverse transcriptase, an enzyme needed for HIV virus replication. Within the NRTI class, abacavir is a carbocyclic nucleoside.
Abacavir was patented in 1988, and approved for use in the United States in 1998. It is on the World Health Organization’s List of Essential Medicines. It is available as a generic medication. Abacavir is used together with other HIV medications, such as abacavir/lamivudine/zidovudine, abacavir/dolutegravir/lamivudine, and abacavir/lamivudine. The combination abacavir/lamivudine is an essential medicine.
Abacavir, in combination with other antiretroviral agents, is indicated for the treatment of HIV-1 infection. Abacavir should be used in combination with other antiretroviral agents.
Abacavir is contraindicated for people who have the HLA‑B*5701 allele or who have moderate or severe liver disease (hepatic impairment).
Common adverse reactions include nausea, headache, fatigue, vomiting, diarrhea, Anorexia (symptom) (loss of appetite), and insomnia (trouble sleeping). Rare but serious side effects include hypersensitivity reaction such as rash, elevated AST and ALT, depression, anxiety, fever/chills, URI, lactic acidosis, hypertriglyceridemia, and lipodystrophy.
Hypersensitivity to abacavir is strongly associated with a specific allele at the human leukocyte antigen B locus namely HLA-B*5701. The mechanism for this hypersensitivity reaction is due to abacavir binding in the antigen-binding cleft of HLA-B*57:01, allowing alternative peptides to bind, which appear as “non-self” when presented to T cells. There is an association between the prevalence of HLA-B*5701 and ancestry. The prevalence of the allele is estimated to be 3.4 to 5.8 percent on average in populations of European ancestry, 17.6 percent in Indian Americans, 3.0 percent in Hispanic Americans, and 1.2 percent in Chinese Americans. There is significant variability in the prevalence of HLA-B*5701 among African populations. In African Americans, the prevalence is estimated to be 1.0 percent on average, 0 percent in the Yoruba from Nigeria, 3.3 percent in the Luhya from Kenya, and 13.6 percent in the Masai from Kenya, although the average values are derived from highly variable frequencies within sample groups.
Common symptoms of abacavir hypersensitivity syndrome include fever, malaise, nausea, and diarrhea. Some patients may also develop a skin rash. Symptoms of AHS typically manifest within six weeks of treatment using abacavir, although they may be confused with symptoms of HIV, immune reconstitution syndrome, hypersensitivity syndromes associated with other drugs, or infection. The U.S. Food and Drug Administration (FDA) released an alert concerning abacavir and abacavir-containing medications on 24 July 2008, and the FDA-approved drug label for abacavir recommends pre-therapy screening for the HLA-B*5701 allele and the use of alternative therapy in subjects with this allele. Additionally, both the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group recommend use of an alternative therapy in individuals with the HLA-B*5701 allele.
Skin-patch testing may also be used to determine whether an individual will experience a hypersensitivity reaction to abacavir, although some patients susceptible to developing AHS may not react to the patch test.
The development of suspected hypersensitivity reactions to abacavir requires immediate and permanent discontinuation of abacavir therapy in all patients, including patients who do not possess the HLA-B*5701 allele. On 1 March 2011, the FDA informed the public about an ongoing safety review of abacavir and a possible increased risk of heart attack associated with the drug. A meta-analysis of 26 studies conducted by the FDA, however, did not find any association between abacavir use and heart attack
The mechanism underlying abacavir hypersensitivity syndrome is related to the change in the HLA-B*5701 protein product. Abacavir binds with high specificity to the HLA-B*5701 protein, changing the shape and chemistry of the antigen-binding cleft. This results in a change in immunological tolerance and the subsequent activation of abacavir-specific cytotoxic T cells, which produce a systemic reaction known as abacavir hypersensitivity syndrome.
Abacavir, and in general NRTIs, do not undergo hepatic metabolism and therefore have very limited (to none) interaction with the CYP enzymes and drugs that effect these enzymes. That being said there are still few interactions that can affect the absorption or the availability of abacavir. Below are few of the common established drug and food interaction that can take place during abacavir co-administration:
Abacavir is a nucleoside reverse transcriptase inhibitor that inhibits viral replication. It is a guanosine analogue that is phosphorylated to carbovir triphosphate (CBV-TP). CBV-TP competes with the viral molecules and is incorporated into the viral DNA. Once CBV-TP is integrated into the viral DNA, transcription and HIV reverse transcriptase is inhibited.
Abacavir is given orally and is rapidly absorbed with a high bioavailability of 83%. Solution and tablet have comparable concentrations and bioavailability. Abacavir can be taken with or without food.
Abacavir can cross the blood–brain barrier. Abacavir is metabolized primarily through the enzymes alcohol dehydrogenase and glucuronyl transferase to an inactive carboxylate and glucuronide metabolites. It has a half-life of approximately 1.5-2.0 hours. If a person has liver failure, abacavir’s half life is increased by 58%.
Abacavir is eliminated via excretion in the urine (83%) and feces (16%). It is unclear whether abacavir can be removed by hemodialysis or peritoneal dialysis.
Robert Vince and Susan Daluge along with Mei Hua, a visiting scientist from China, developed the medication in the ’80s.
Abacavir was approved by the U.S. Food and Drug Administration (FDA) on 18 December 1998, and is thus the fifteenth approved antiretroviral drug in the United States. Its patent expired in the United States on 26 December 2009.[citation needed]
Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Abacavir Sulfate and Weed and an increase in anxiety.
Anyone mixing Abacavir Sulfate and weed is likely to experience side effects. This happens with all medications whether weed or Abacavir Sulfate is mixed with them. Side effects can be harmful when mixing Abacavir Sulfate and weed. Doctors are likely to refuse a patient a Abacavir Sulfate prescription if the individual is a weed smoker or user. Of course, this could be due to the lack of studies and research completed on the mixing of Abacavir Sulfate and Weed.
Heavy, long-term weed use is harmful for people. It alters the brain’s functions and structure, and all pharmaceuticals and drugs including Abacavir Sulfate are designed to have an impact on the brain. There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Abacavir Sulfate. For example, simple painkiller medication does not heal the injury, it simply interrupts the brains functions to receive the pain cause by the injury. To say then that two drugs, Abacavir Sulfate and Weed, dol not interact is wrong. There will always be an interaction between Abacavir Sulfate and Weed in the brain11.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/.
One of the milder side effects of mixing Abacavir Sulfate and Weed is Scromiting. This condition, reportedly caused by mixing Abacavir Sulfate and Weed, describes a marijuana-induced condition where the user experiences episodes of violent vomiting, which are often so severe and painful that they cause the person to scream. The medical term for Scromiting by mixing Abacavir Sulfate and Weed is cannabinoid hyperemesis syndrome, or CHS. For these reasons, some people choose to quit smoking weed.
It was first included in scientific reports in 2004. Since then, researchers have determined that Scromiting is the result of ongoing, long-term use of marijuana—particularly when the drug contains high levels of THC, marijuana’s main psychoactive ingredient. Some experts believe that the receptors in the gut become overstimulated by THC, thus causing the repeated cycles of vomiting.
In the long run, a person can become even more depressed. There is a belief that marijuana is all-natural and not harmful to a person’s health. This is not true and Abacavir Sulfate and weed can cause health issues the more a person consumes it.
How does Weed effect the potency of Abacavir Sulfate?
The way in which the body absorbs and process Abacavir Sulfate may be affected by weed. Therefore, the potency of the Abacavir Sulfate may be less effective. Marijuana inhibits the metabolization of Abacavir Sulfate. Not having the right potency of Abacavir Sulfate means a person may either have a delay in the relief of their underlying symptoms.
A person seeking Abacavir Sulfate medication that uses weed should speak to their doctor. It is important the doctor knows about a patient’s weed use, so they can prescribe the right Abacavir Sulfate medication and strength. Or depending on level of interactions they may opt to prescribe a totally different medication. It is important for the doctor to know about their patient’s marijuana use. Weed is being legalized around the US, so doctors should be open to speaking about a patient’s use of it.
Sideffects of Abacavir Sulfate and Weed
Many individuals may not realize that there are side effects and consequences to mixing Abacavir Sulfate and Weed such as:
- Dizziness
- Sluggishness
- Drowsiness
- Shortness of breath
- Itching
- Hives
- Palpitations
- Respiratory Depression
- Cardiac Arrest
- Coma
- Seizures
- Death
Interestingly, it is impossible to tell what effect mixing this substance with Weed will have on an individual due to their own unique genetic make up and tolerance. It is never advisable to mix Abacavir Sulfate and Weed due to the chances of mild, moderate and severe side effects. If you are having an adverse reaction from mixing Abacavir Sulfate and Weed it’s imperative that you head to your local emergency room. Even mixing a small amount of Abacavir Sulfate and Weed is not recommended.
Taking Abacavir Sulfate and Weed together
People who take Abacavir Sulfate and Weed together will experience the effects of both substances. Technically, the specific effects and reactions that occur due to frequent use of Abacavir Sulfate and weed depend on whether you consume more weed in relation to Abacavir Sulfate or more Abacavir Sulfate in relation to weed.
The use of significantly more weed and Abacavir Sulfate will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Abacavir Sulfate may experience effects such as:
- reduced motor reflexes from Abacavir Sulfate and Weed
- dizziness from Weed and Abacavir Sulfate
- nausea and vomiting due to Abacavir Sulfate and Weed
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Abacavir Sulfate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Mixing weed and Abacavir Sulfate
The primary effect of weed is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, and by a reduction in its effect on neuronal transmitters. When weed is combined with Abacavir Sulfate this primary effect is exaggerated, increasing the strain on the body with unpredictable results.
Weed and Abacavir Sulfate affects dopamine levels in the brain, causing the body both mental and physical distress. Larger amounts of Abacavir Sulfate and weed have a greater adverse effect yet leading medical recommendation is that smaller does of Abacavir Sulfate can be just as harmful and there is no way of knowing exactly how Abacavir Sulfate and weed is going to affect an individual before they take it.
Taking Abacavir Sulfate and weed together
People who take Abacavir Sulfate and weed together will experience the effects of both substances. The use of significantly more Abacavir Sulfate with weed will lead to sedation and lethargy, as well as the synergistic effects resulting from a mixture of the two medications.
People who take both weed and Abacavir Sulfate may experience effects such as:
- reduced motor reflexes from Abacavir Sulfate and weed
- dizziness from weed and Abacavir Sulfate
- nausea and vomiting of the Abacavir Sulfate
Some people may also experience more euphoria, depression, irritability or all three. A combination of weed and Abacavir Sulfate leads to significantly more lethargy which can easily tip over into coma, respiratory depression seizures and death.
Weed Vs Abacavir Sulfate
Taking Abacavir Sulfate in sufficient quantities increases the risk of a heart failure. Additionally, people under the influence of Abacavir Sulfate and weed may have difficulty forming new memories. With weed vs Abacavir Sulfate in an individual’s system they become confused and do not understand their environment. Due to the synergistic properties of Abacavir Sulfate when mixed with weed it can lead to confusion, anxiety, depression and other mental disorders. Chronic use of Abacavir Sulfate and weed can lead to permanent changes in the brain22.G. Lafaye, L. Karila, L. Blecha and A. Benyamina, Cannabis, cannabinoids, and health – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741114/.
Abacavir Sulfate Vs Weed
Studies investigating the effects of drugs such as Abacavir Sulfate and weed have shown that the potential for parasomnia (performing tasks in sleep) is dramatically increased when Abacavir Sulfate and weed are combined. Severe and dangerous side effects can occur when medications are mixed in the system, and sleep disorders are a common side effect of taking weed and Abacavir Sulfate together.
When a small to medium amount of weed is combined with Abacavir Sulfate, sleep disorders such as sleep apnea can occur. According to the latest data from the US Centers for Disease Control and Prevention (CDC) most ER visits and hospitalizations caused by too much weed were associated with other substances such as Abacavir Sulfate.
How long after taking Abacavir Sulfate can I smoke weed or take edibles?
To avoid any residual toxicity it is advisable to wait until the Abacavir Sulfate has totally cleared your system before taking weed, even in small quantities.
Overdose on Abacavir Sulfate and weed
In the case of Overdose on Abacavir Sulfate or if you are worried after mixing Abacavir Sulfate and weed, call a first responder or proceed to the nearest Emergency Room immediately.
If you are worried about someone who has taken too much Abacavir Sulfate or mixed weed with Abacavir Sulfate then call a first responder or take them to get immediate medical help. The best place for you or someone you care about in the case of a medical emergency is under medical supervision. Be sure to tell the medical team that there is a mix of Abacavir Sulfate and weed in their system.
Excessive Weed intake and result in scromiting, chs, and anxiety disorder. It is advisable to quit vaping weed if you are feeling these symptoms.
Mixing Abacavir Sulfate and weed and antidepressants
Weed users feeling depressed and anxious may be prescribed antidepressant medication. There are some antidepressant users who also use Abacavir Sulfate and weed. These individuals may not realize that there are side effects and consequences to consuming both Abacavir Sulfate, marijuana and a range of antidepressants.
Studies on weed, Abacavir Sulfate and antidepressants is almost nil. The reason for so little information on the side effects of the two is mostly down to marijuana being illegal in most places – although a number of states in the United States have legalized the drug.
Self-medicating with Weed and Abacavir Sulfate
A lot of people suffer from depression caused by weed and Abacavir Sulfate. How many? According to Anxiety and Depression Association of America (ADAA), in any given year, it is estimated that nearly 16 million adults experience depression. Unfortunately, that number is likely to be wrong due to under reporting. Many people do not report suffering from depression because they do not want to be looked at as suffering from a mental illness. The stigmas around mental health continue and people do not want to be labeled as depressed.
Potential side effects from mixing Abacavir Sulfate and weed
Quitting weed to take Abacavir Sulfate
Medical professionals say an individual prescribed or taking Abacavir Sulfate should not stop using weed cold turkey. Withdrawal symptoms can be significant. Heavy pot users should especially avoid going cold turkey. The side effects of withdrawal from weed include anxiety, irritability, loss of sleep, change of appetite, and depression by quitting weed cold turkey and starting to take Abacavir Sulfate.
A person beginning to use Abacavir Sulfate should cut back on weed slowly. While reducing the amount of weed use, combine it with mindfulness techniques and/or yoga. Experts stress that non-medication can greatly improve a person’s mood.
Weed and Abacavir Sulfate can affect a person in various ways. Different types of marijuana produce different side effects. Side effects of weed and Abacavir Sulfate may include:
- loss of motor skills
- poor or lack of coordination
- lowered blood pressure
- short-term memory loss
- increased heart rate
- increased blood pressure
- anxiety
- paranoia
- increased energy
- increased motivation
Mixing Abacavir Sulfate and weed can also produce hallucinations in users. This makes marijuana a hallucinogenic for some users. Weed creates different side effects in different people, making it a very potent drug. Now, mixing Abacavir Sulfate or other mental health drugs with weed can cause even more unwanted side effects.
Mixing drugs and weed conclusion
Long-term weed use can make depression and anxiety worse. In addition, using marijuana can prevent Abacavir Sulfate from working to their full potential33.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use – PMC, PubMed Central (PMC).; Retrieved September 27, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678684/. Weed consumption should be reduced gradually to get the most out of prescription medication. Marijuana is a drug and it is harmful to individual’s long-term health. Weed has many side effects and the consequences are different to each person who uses it, especially when mixed with Abacavir Sulfate.
If you take Abacavir Sulfate, and also drink Alcohol or MDMA, you can research the effects of Abacavir Sulfate and Alcohol , Abacavir Sulfate and Cocaine as well as Abacavir Sulfate and MDMA here.
To find the effects of other drugs and weed refer to our Weed and Other Drugs Index A to L or our Weed and Other Drugs Index M-Z.
Or you could find what you are looking for in our Alcohol and Interactions with Other Drugs index A to L or Alcohol and Interactions with Other Drugs index M to Z , Cocaine and Interactions with Other Drugs index A to L or Cocaine and Interactions with Other Drugs index M to Z or our MDMA and Interactions with Other Drugs Index A to L or MDMA and Interactions with Other Drugs Index M to Z.
Abacavir Sulfate and Weed
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